N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

Base Information

Chemical Name:N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride
CAS No.:226395-87-5
Molecular Formula:C₁₉H₁₉F₃N₂O₆S*ClH
Molecular Weight:496.892
Hs Code.:

Synonyms:N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

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Chemical Property of N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

There total 5 articles about N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 226400-31-3
C₂₉H₃₅F₃N₂O₉S

: 226395-87-5
N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1021/jm100669j

Reference yield:

: 226401-67-8
C₂₆H₃₀F₃NO₈S

: 226395-87-5
N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 24 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 226400-29-9
C₂₄H₂₆F₃NO₈S

: 226395-87-5
N-hydroxy-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;