1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE

Base Information

• Chemical Name: 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE
• CAS No.: 226396-63-0
• Molecular Formula: C19H27FNO6S
• Molecular Weight: 415.483
• Mol file: 226396-63-0.mol

Synonyms:1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE

Chemical Property of 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE

Chemical Property:

• PSA: 98.36000
• LogP: 3.95090

Purity/Quality:

1-TERT-BUTYL-4-ETHYL-4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE

There total 5 articles about 1-TERT-BUTYL 4-ETHYL 4-(4-FLUOROPHENYLSULFONYL)PIPERIDINE-1,4-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

1-tert-butyl 4-ethyl 4-[(4-fluorophenyl)thio]piperidine-1,4-dicarboxylate (226396-62-9) → 1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate (226396-63-0)

Guidance literature:

With phthalic anhydride; urea hydrogen peroxide adduct; In ethyl acetate; at 15 - 20 ℃; for 18h;

Reference yield:

bis(4-fluorophenyl)disulfide (405-31-2) → 1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate (226396-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 1.5 h / 0 °C

1.2: 75 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 60 percent / MCPBA / CH₂Cl₂ / 20 h / 0 °C

With 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0500875

Reference yield:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → 1-(tert-butyl) 4-ethyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1,4-dicarboxylate (226396-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 1.5 h / 0 °C

1.2: 75 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 60 percent / MCPBA / CH₂Cl₂ / 20 h / 0 °C

With 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0500875

upstream raw materials:

1-tert-butyl 4-ethyl 4-[(4-fluorophenyl)thio]piperidine-1,4-dicarboxylate

bis(4-fluorophenyl)disulfide

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

4-Fluorothiophenol

Downstream raw materials:

1-tert-butyl 4-ethyl 4-{[4-(phenylthio)phenyl]sulfonyl}piperidine-1,4-dicarboxylate

C₂₆H₃₁NO₉S

C₂₆H₃₀F₃NO₇S

C₂₇H₃₅NO₈S

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