2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one

Base Information

• Chemical Name: 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one
• CAS No.: 217956-58-6
• Molecular Formula: C₁₉H₁₇NO₂
• Molecular Weight: 291.349

Synonyms:2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one

Chemical Property of 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one

There total 3 articles about 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-benzylphthalimide (2142-01-0) + 1-Bromo-2-butyne (3355-28-0) → 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one (217956-58-6)

Guidance literature:

With magnesium; mercury dichloride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(98)00897-7

Reference yield:

benzyl bromide (100-39-0) → 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one (217956-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / dimethylformamide / Heating

2: 98 percent / Mg, HgCl₂ / tetrahydrofuran / 2 h / 0 °C

With magnesium; mercury dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(98)00897-7

Reference yield:

potassium phtalimide (1074-82-4) → 2-Benzyl-3-hydroxy-3-(1-methyl-propa-1,2-dienyl)-2,3-dihydro-isoindol-1-one (217956-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / dimethylformamide / Heating

2: 98 percent / Mg, HgCl₂ / tetrahydrofuran / 2 h / 0 °C

With magnesium; mercury dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(98)00897-7

upstream raw materials:

N-benzylphthalimide

1-Bromo-2-butyne

benzyl bromide

potassium phtalimide

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