tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

Base Information

Chemical Name:tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate
CAS No.:1246527-49-0
Molecular Formula:C₃₀H₃₀F₃N₃O₃
Molecular Weight:537.582
Hs Code.:

Synonyms:tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

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Chemical Property of tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

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Technology Process of tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

There total 9 articles about tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140462-04-9
2’-methyl-2-(trifluoromethyl)biphenyl-4-carboxylic acid

: 1141474-21-6
tert-butyl [{3-[amino(hydroxyimino)methyl]benzyl}(methyl)amino]acetate

: 1246527-49-0
tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile; at 20 - 150 ℃; for 2.5h; Microwave irradiation;

Reference yield:

: 28188-41-2
m-(bromomethyl)benzonitrile

: 1246527-49-0
tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 15 h / 20 °C

2: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

3: coupling reagent / 0 - 20 °C / Inert atmosphere

4: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: 1141474-22-7
tert-butyl [(3-cyanobenzyl)(methyl)amino]acetate

: 1246527-49-0
tert-butyl N-methyl-N-(3-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

2: coupling reagent / 0 - 20 °C / Inert atmosphere

3: acetonitrile / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; In ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557