(3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

Base Information

Chemical Name:(3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one
CAS No.:861708-99-8
Molecular Formula:C₁₇H₂₄N₂O₂
Molecular Weight:288.39
Hs Code.:

Synonyms:(3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

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Chemical Property of (3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

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Technology Process of (3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

There total 4 articles about (3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 861708-87-4
(2E)-N-((1R)-1-methyl-3-oxopropyl)-N-((1S)-1-phenylethyl)but-2-enamide

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 861708-99-8
(3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

Guidance literature:: With triethylamine; In ethanol; for 24h; Heating;
DOI:10.1002/ejoc.200400847

Reference yield:

: 861708-80-7
(2E)-N-((1R)-3-hydroxy-1-methylpropyl)-N-((1S)-1-phenylethyl)but-2-enamide

: 861708-99-8
(3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / bis(trichloromethyl) carbonate; triethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / -78 - 20 °C

2: 81 percent / triethylamine / ethanol / 24 h / Heating

With bis(trichloromethyl) carbonate; triethylamine; In ethanol; dichloromethane; dimethyl sulfoxide; 1: Swern-like oxidation;
DOI:10.1002/ejoc.200400847

Reference yield:

: 1026559-28-3
(E)-But-2-enoic acid (R)-3-[((E)-but-2-enoyl)-((S)-1-phenyl-ethyl)-amino]-butyl ester

: 861708-99-8
(3R,3aS,6R,7aR)-1,3,6-trimethyl-5-((1S)-1-phenylethyl)hexahydroisoxazolo[4,3-c]pyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 4.44 g / aq. K₂CO₃ / methanol / 3 h / 20 °C

2: 65 percent / bis(trichloromethyl) carbonate; triethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / -78 - 20 °C

3: 81 percent / triethylamine / ethanol / 24 h / Heating

With bis(trichloromethyl) carbonate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; 2: Swern-like oxidation;
DOI:10.1002/ejoc.200400847