Glycerol-1,1,2,3,3-d5

Base Information

• Chemical Name: Glycerol-1,1,2,3,3-d5
• CAS No.: 62502-71-0
• Molecular Formula: C3H3D5O3
• Molecular Weight: 97.055
• DSSTox Substance ID: DTXSID60472007
• Nikkaji Number: J1.506.143J
• Wikidata: Q82300741
• Mol file: 62502-71-0.mol

Synonyms:Glycerol-1,1,2,3,3-d5;62502-71-0;glycerol-d5;1,1,2,3,3-pentadeuteriopropane-1,2,3-triol;Propanetriol-d5;Glyceritol-d5;Glycerol D5;(?H?)propane-1,2,3-triol;DTXSID60472007;HY-B1659S6;AKOS015913677;CS-0534893;Glycerol-1,1,2,3,3-d5, 98 atom % D;D97882;1,2,3-PROPANETRIOL-1,1,2,3,3-D5;A935600;Glycerol-1,1,2,3,3-d5, S & P tested, 98 atom % D;Glycerol-1,1,2,3,3-d5, 98 atom % D, 99% (CP), meets EP, USP testing specifications

Chemical Property of Glycerol-1,1,2,3,3-d5

Chemical Property:

• Appearance/Colour: colorless liquid
• Melting Point: 20 °C(lit.)
• Refractive Index: n20/D 1.472(lit.)
• Boiling Point: 289.999 °C at 760 mmHg
• Flash Point: 160 °C
• PSA: 60.69000
• Density: 1.369 g/cm³
• LogP: -1.66810
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 97.078727843
• Heavy Atom Count: 6
• Complexity: 25.2

Purity/Quality:

NLT 98% ^*data from raw suppliers

Glycerol-d5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(CO)O)O
• Isomeric SMILES: [2H]C([2H])(C([2H])(C([2H])([2H])O)O)O
• Uses: Labelled Glycerol . Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is al Glycerol-d5 is a Labeled compound . It is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. It is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.

Technology Process of Glycerol-1,1,2,3,3-d5

There total 3 articles about Glycerol-1,1,2,3,3-d5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → [1,1,2,3,3-2H5]glycerol (62502-71-0)

Guidance literature:

With 5% activated charcoal-supported ruthenium catalyst; hydrogen; water-d2; at 80 ℃; for 24h; under 760.051 Torr; regioselective reaction;

DOI:10.1002/adsc.200800407

Reference yield: 60.0%

Diethyl ketomalonate (609-09-6) → [1,1,2,3,3-2H5]glycerol (62502-71-0)

Guidance literature:

With lithium aluminium deuteride; In tetrahydrofuran; for 1h; Heating;

Reference yield:

→ [1,1,2,3,3-2H5]glycerol (62502-71-0)

Guidance literature:

Diethylketomalonat + LiAlD4.;

DOI:10.1016/0009-3084(79)90083-5

upstream raw materials:

Diethyl ketomalonate

glycerol

Downstream raw materials:

2-oleoyl glycerol-d5

2-arachidonoyl glycerol-d5

2,2-dimethyl-4-(1,1-dideuterated)hydroxymethyl-4,5,5-trideuterated-1,3-dioxolane

propan-1-ol

Refernces

• 1、 Maegawa, Tomohiro,Fujiwara, Yuta,Inagaki, Yuya,Monguchi, Yasunari,Sajiki, Hironao. "A convenient and effective method for the regioselective deuteration of alcohols". supporting information; experimental part. p. 2215 - 2218. Retrieved 2009/10/02.
• 2、 Bersch, B.,Starck, J. P.,Milon, A.,Nakatani, Y.,Ourisson, G.. "Total synthesis of perdeuterated phospholipids". . p. 575 - 583. Retrieved 2007/10/02.