(3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

Base Information

Chemical Name:(3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol
CAS No.:913355-86-9
Molecular Formula:C₂₄H₃₃ClO₃Si
Molecular Weight:433.063
Hs Code.:

Synonyms:(3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

Chemical Property:

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Technology Process of (3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

There total 7 articles about (3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913355-76-7
C₃₀H₄₇ClO₃Si₂

: 913355-86-9
(3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol;
DOI:10.1002/anie.200601655

Reference yield:

: 865872-30-6
tert-butyl-((3R,4R)-4-chloro-3-methoxyhex-5-enyloxy)dimethylsilane

: 913355-86-9
(3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₃[Fe(CN)6]; hydroquinine 2,5-diphenyl-4,6-pyrimidinediyl diether; OsO₄ / 2-methyl-propan-2-ol; H₂O

2.1: pyridine

3.1: potassium carbonate / methanol

4.1: nBuLi / tetrahydrofuran / 0 °C

4.2: tetrahydrofuran / 0 °C

5.1: imidazole

6.1: pyridinium para-toluenesulfonate / methanol

With pyridine; 1H-imidazole; osmium(VIII) oxide; n-butyllithium; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); pyridinium p-toluenesulfonate; potassium carbonate; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1002/anie.200601655

Reference yield:

: 865872-29-3
(3R,4R)-1-(tert-butyldimethylsilanyloxy)-4-chlorohex-5-en-3-ol

: 913355-86-9
(3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-chloro-3-methoxy-hept-6-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: proton sponge

2.1: K₃[Fe(CN)6]; hydroquinine 2,5-diphenyl-4,6-pyrimidinediyl diether; OsO₄ / 2-methyl-propan-2-ol; H₂O

3.1: pyridine

4.1: potassium carbonate / methanol

5.1: nBuLi / tetrahydrofuran / 0 °C

5.2: tetrahydrofuran / 0 °C

6.1: imidazole

7.1: pyridinium para-toluenesulfonate / methanol

With pyridine; 1H-imidazole; osmium(VIII) oxide; n-butyllithium; Proton Sponge; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); pyridinium p-toluenesulfonate; potassium carbonate; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1002/anie.200601655