(2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

Base Information

Chemical Name:(2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol
CAS No.:141100-81-4
Molecular Formula:C₃₁H₃₈O₅
Molecular Weight:490.64
Hs Code.:

Synonyms:(2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

Suppliers and Price of (2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

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Chemical Property of (2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

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Technology Process of (2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

There total 5 articles about (2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 109-72-8,29786-93-4
n-butyllithium

: 74372-90-0
3,4,6-tri-O-benzyl-D-glucal epoxide

: 141100-81-4
(2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

Guidance literature:: n-butyllithium; With zinc(II) chloride; In diethyl ether;

3,4,6-tri-O-benzyl-D-glucal epoxide; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1055/s-2003-38751

Reference yield:

: 693-04-9
butyl magnesium bromide

: 74372-90-0
3,4,6-tri-O-benzyl-D-glucal epoxide

: 141100-81-4
(2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

: 909714-58-5
(2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

Guidance literature:: butyl magnesium bromide; With zinc(II) chloride;

3,4,6-tri-O-benzyl-D-glucal epoxide; In dichloromethane; at 0 - 20 ℃; for 4h; Title compound not separated from byproducts;
DOI:10.1055/s-2003-38751

Reference yield:

: 55628-54-1
3,4,6-tri-O-benzyl-D-glucal

: 141100-81-4
(2R,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-butyl-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyldioxirane / CH₂Cl₂ / 0 °C

2: diethyl ether / -78 °C

With 3,3-dimethyldioxirane; In diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2007.04.060