2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid

Base Information

• Chemical Name: 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid
• CAS No.: 121809-76-5
• Molecular Formula: C₁₇H₁₇ClN₂O₄
• Molecular Weight: 348.786
• Mol file: 121809-76-5.mol

Synonyms:2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid

Chemical Property of 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid

There total 9 articles about 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(4-aminophenoxy)-2-methyl propionic acid (117011-70-8) + p-chlorphenylisocyanate (104-12-1) → 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid (121809-76-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00130a021

Reference yield:

(4-hydroxyphenyl)carbamic acid ethyl ester (7159-95-7) → 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid (121809-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / NaOH / 4 h / Heating

2: 87 percent / 10percent KOH / 0.5 h / Heating

3: 86 percent / 2 N NaOH / tetrahydrofuran

With potassium hydroxide; sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00130a021

Reference yield:

4-amino-phenol (123-30-8) → 2-{4-[3-(4-Chloro-phenyl)-ureido]-phenoxy}-2-methyl-propionic acid (121809-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature

2: NaOH / Heating

With sodium hydroxide; In pyridine;

DOI:10.1021/jm00130a021

upstream raw materials:

2-(4-aminophenoxy)-2-methyl propionic acid

p-chlorphenylisocyanate

chloroform

1-(4-chlorophenyl)-3-(4-hydroxyphenyl)urea