C₂₃H₂₃N₂O₂⁽¹⁺⁾*Br^(1-)

Base Information

• Chemical Name: C₂₃H₂₃N₂O₂⁽¹⁺⁾*Br^(1-)
• CAS No.: 1412271-07-8
• Molecular Formula: Br*C₂₃H₂₃N₂O₂
• Molecular Weight: 439.352
• Mol file: 1412271-07-8.mol

Synonyms:C₂₃H₂₃N₂O₂⁽¹⁺⁾*Br^(1-)

Chemical Property of C₂₃H₂₃N₂O₂⁽¹⁺⁾*Br^(1-)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₃N₂O₂⁽¹⁺⁾*Br^(1-)

There total 9 articles about C₂₃H₂₃N₂O₂⁽¹⁺⁾*Br^(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C15H16N2O (1412272-43-5) + α-bromoacetophenone (70-11-1) → C23H23N2O2(1+)*Br(1-) (1412271-07-8)

Guidance literature:

In toluene; Reflux;

DOI:10.2174/1570180811310070003

Reference yield:

3-(2,3-dihydro-1-benzofuran-5-yl)propanoic acid (215057-28-6) → C23H23N2O2(1+)*Br(1-) (1412271-07-8)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride / 0.67 h / 80 °C

2: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / 20 °C / Cooling with ice

3: sodium tetrahydroborate / ethanol; dichloromethane / 4 h / 0 - 20 °C

4: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

5: 1,4-dioxane / Reflux

6: toluene / Reflux

With aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.2174/1570180811310070003

Reference yield:

2,3-dihydro-benzofuran-5-carbaldehyde (55745-70-5) → C23H23N2O2(1+)*Br(1-) (1412271-07-8)

Guidance literature:

Multi-step reaction with 8 steps

1: piperidine / pyridine / 4 h / Reflux

2: palladium 10% on activated carbon; hydrogen / acetic acid / 1 h / 20 °C

3: thionyl chloride / 0.67 h / 80 °C

4: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / 20 °C / Cooling with ice

5: sodium tetrahydroborate / ethanol; dichloromethane / 4 h / 0 - 20 °C

6: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

7: 1,4-dioxane / Reflux

8: toluene / Reflux

With piperidine; aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; pyridine; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;

DOI:10.2174/1570180811310070003

upstream raw materials:

2.3-dihydrobenzofuran

2,3-dihydro-benzofuran-5-carbaldehyde

3-(2,3-dihydro-1-benzofuran-5-yl)-2-propenoic acid

C₁₅H₁₆N₂O

Refernces

• 1、 Chen, Wen,Yang, Li-Juan,Li, Yan,Wang, Xue-Quan,Wang, Shao-Jie,Wan, Wei-Chao,Zhang, Hong-Bin,Yang, Xiao-Dong. "Novel tricyclic indeno[5,6-b]furan-imidazole hybrid compounds: Design, synthesis and antitumor activity". . p. 561 - 571. Retrieved 2013/08/23.