N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

Base Information

Chemical Name:N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine
CAS No.:84110-17-8
Molecular Formula:C₂₈H₂₉NO₅
Molecular Weight:459.542
Hs Code.:

Synonyms:N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

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Chemical Property of N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

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Technology Process of N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

There total 6 articles about N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R,4R)-2-[1-(4-Methoxy-phenyl)-ethyl]-pyrrolidine-3,4-diol

: 84110-10-1
9-fluorenylmethyl 4,6-dimethyl-2-pyrimidylthiocarbonate

: 84110-17-8
N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at 45 ℃; for 1h;
DOI:10.1021/jm00358a003

Reference yield:

: 84109-94-4
2-(α-methyl-p-methoxybenzyl)-3-pyrroline

: 84110-17-8
N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / 2N NaOH / toluene / 1 h / 3 - 5 °C

2: 70percent perchloric acid, N-iodosuccinimide / tetrahydrofuran; H₂O / 1 h / 3 - 25 °C

3: 5percent KOH / ethanol / 0.5 h

4: 82 percent / HOAc, Zn / tetrahydrofuran / 1 h

5: sodium trifluoroacetate, trifluoroacetic acid / 16 h / Heating

6: 10percent Na₂CO₃ / tetrahydrofuran / 1 h / 45 °C

With potassium hydroxide; sodium hydroxide; N-iodo-succinimide; perchloric acid; sodium 2,2,2-trifluoroacetate; sodium carbonate; acetic acid; trifluoroacetic acid; zinc; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jm00358a003

Reference yield:

: 84110-16-7
(1S,2R,5R)-2-[1-(4-Methoxy-phenyl)-ethyl]-6-oxa-3-aza-bicyclo[3.1.0]hexane

: 84110-17-8
N-<(fluorenylmethoxy)carbonyl>-3β,4α-dihydroxy-2β-(α-methyl-p-methoxybenzyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium trifluoroacetate, trifluoroacetic acid / 16 h / Heating

2: 10percent Na₂CO₃ / tetrahydrofuran / 1 h / 45 °C

With sodium 2,2,2-trifluoroacetate; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00358a003