4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

Base Information

Chemical Name:4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile
CAS No.:178308-82-2
Molecular Formula:C₂₂H₂₀ClN₅O₂
Molecular Weight:421.886
Hs Code.:

Synonyms:4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

Suppliers and Price of 4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

There total 4 articles about 4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 178309-43-8
4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine

: 178308-82-2
4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 12h;
DOI:10.1021/jm9905054

Reference yield:

: 178308-65-1
1-(4-hydroxypiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine

: 178309-43-8
4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine

: 178308-82-2
4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

: 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4-oxopiperidino)phthalazine hydrochloride

Guidance literature:: With sodium hydrogencarbonate; In hexane; dichloromethane; trifluoroacetic acid;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 178308-82-2
4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂EtN; NMP / 4.5 h / 170 °C

2: 80 percent / TFA / 12 h / 20 °C

With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1: Condensation / 2: Hydrolysis;
DOI:10.1021/jm9905054