4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine

Base Information

• Chemical Name: 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine
• CAS No.: 178309-43-8
• Molecular Formula: C₂₄H₂₄ClN₅O₃
• Molecular Weight: 465.939

Synonyms:4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine

Chemical Property of 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine

Chemical Property:

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Technology Process of 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine

There total 1 articles about 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4-ethylenedioxy-piperidine (177-11-7) + 1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine (178308-63-9) → 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine (178309-43-8)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine; at 170 ℃; for 4.5h;

DOI:10.1021/jm9905054

Reference yield: 80.0%

4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine (178309-43-8) → 4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile (178308-82-2)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 12h;

DOI:10.1021/jm9905054

Reference yield:

1-(4-hydroxypiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine (178308-65-1) + 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4,4-ethylenedioxypiperidino)phthalazine (178309-43-8) → 4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile (178308-82-2) + 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-(4-oxopiperidino)phthalazine hydrochloride

Guidance literature:

With sodium hydrogencarbonate; In hexane; dichloromethane; trifluoroacetic acid;

upstream raw materials:

4,4-ethylenedioxy-piperidine

1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine

Downstream raw materials:

4-[(3-chloro-4-methoxybenzyl)amino]-1-[4-oxopiperidino]-6-phthalazine carbonitrile

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