4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ⁴-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol

Base Information

• Chemical Name: 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ⁴-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol
• CAS No.: 128721-26-6
• Molecular Formula: C₂₅H₃₀N₂O₅S₃
• Molecular Weight: 534.722

Synonyms:4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ⁴-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol

Chemical Property of 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ⁴-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol

Chemical Property:

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Technology Process of 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ⁴-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol

There total 7 articles about 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ⁴-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol (128721-21-1) → 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ4-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol (128721-26-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at -20 ℃; for 6h;

DOI:10.3987/COM-89-5240

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ4-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol (128721-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) THF, -40 deg C, 15 min, 2.) -40 deg C, 45 min

2: 42 percent / 85percent MCPBA / CH₂Cl₂; H₂O / 6 h / -20 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

DOI:10.3987/COM-89-5240

Reference yield:

indole (120-72-9) → 4-{2-[1-(4-Methoxy-benzenesulfonyl)-1H-indol-2-yl]-1-oxo-1λ4-[1,3]dithian-2-yl}-1-methyl-piperidin-4-ol (128721-26-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / tetrabutylammonium hydrogensulfate, 50percent aq. NaOH / benzene / 16 h / Ambient temperature

2: 1.) diisopropylamine, n-butyllithium / 1.) THF, 0 deg C, 30 min, 2.) RT, 5 h

3: 95 percent / p-toluenesulfonic acid / toluene / 15 h / Heating

4: 1.) n-butyllithium / 1.) THF, -40 deg C, 15 min, 2.) -40 deg C, 45 min

5: 42 percent / 85percent MCPBA / CH₂Cl₂; H₂O / 6 h / -20 °C

With sodium hydroxide; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; toluene; benzene;

DOI:10.3987/COM-89-5240

upstream raw materials:

1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

1-Methyl-4-piperidone

indole

1-((4-methoxyphenyl)sulfonyl)-1H-indole

Downstream raw materials:

1-(4-methoxyphenylsulfonyl)-2-indolyl 1-methyl-4-hydroxy-4-piperidyl ketone

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