3-Pyrrolidineacetic acid

Base Information

• Chemical Name: 3-Pyrrolidineacetic acid
• CAS No.: 89203-64-5
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 2933990090
• Mol file: 89203-64-5.mol

Synonyms:Pyrrolidin-3-ylaceticacid;

Chemical Property of 3-Pyrrolidineacetic acid

Chemical Property:

• Vapor Pressure: 0.0017mmHg at 25°C
• Refractive Index: 1.47
• Boiling Point: 272.3 °C at 760 mmHg
• Flash Point: 118.5 °C
• PSA: 49.33000
• Density: 1.104 g/cm³
• LogP: 0.39940
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(Pyrrolidin-3-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Pyrrolidin-3-yl)acetic Acid is used in preparation of Xanthone derivatives for treatment and prophylaxis of hepatitis B. Also, used in preparation of Naphthalenes and Quinolines as ATX modulating agents.

Technology Process of 3-Pyrrolidineacetic acid

There total 4 articles about 3-Pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-Ethoxycarbonylmethyl-pyrrolidine-1-carboxylic acid ethyl ester → 3-pyrrolidine ethanoic acid (89203-64-5)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1016/0040-4020(96)00734-X

Reference yield:

ethyl 1-methoxycarbonyl-2-pyrroline-3-acetate (85310-61-8) → 3-pyrrolidine ethanoic acid (89203-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / H₂ / Rh-Al₂O₃ / ethanol / 20 h / 2250.2 Torr

2: 1.) 5 M HCl, 2.) Et₃N / 1.) reflux, 2 h, 2.) EtOH

With hydrogenchloride; hydrogen; triethylamine; rhodium on alumina; In ethanol;

Reference yield:

Benzyl-but-3-enyl-tributylstannanylmethyl-amine → 3-pyrrolidine ethanoic acid (89203-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) hexane, Et₂O, a) from -78 deg C to RT, 30 min, b) RT, 2 h, 2.) hexane, Et₂O, -78 deg C

2: 71 percent / 6 M aq. HCl / 4 h / Heating

With hydrogenchloride; n-butyllithium;

DOI:10.1016/0040-4020(96)00734-X

upstream raw materials:

(RS)-ethyl 1-methoxycarbonyl-3-pyrrolidineacetate

ethyl 1-methoxycarbonyl-2-pyrroline-3-acetate

Downstream raw materials:

(R,S)-Fmoc-pyrrolidine-3-acetic acid