1-FMOC-3-PYRROLIDINEACETIC ACID

Base Information

• Chemical Name: 1-FMOC-3-PYRROLIDINEACETIC ACID
• CAS No.: 868523-86-8
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.402
• Hs Code.: 2933998090
• Mol file: 868523-86-8.mol

Synonyms:

Chemical Property of 1-FMOC-3-PYRROLIDINEACETIC ACID

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-Fmoc-3-pyrrolidin-3-yl-aceticacid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-FMOC-3-PYRROLIDINEACETIC ACID

There total 1 articles about 1-FMOC-3-PYRROLIDINEACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + 3-pyrrolidine ethanoic acid (89203-64-5) → (R,S)-Fmoc-pyrrolidine-3-acetic acid (868523-86-8)

Guidance literature:

With sodium hydrogencarbonate; In acetone;

DOI:10.1021/jm050513m

Reference yield:

(R,S)-Fmoc-pyrrolidine-3-acetic acid (868523-86-8) + Fmoc-Leu-OH (35661-60-0) + Fmoc-Pro-OH (71989-31-6) + acetic anhydride (108-24-7) + (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4(bis(dimethylamino)phosphoryloxy)phenyl)propanoic acid (172611-23-3) → Phosphoric acid mono-[4-((S)-2-acetylamino-2-{(S)-1-[(S)-2-(3-carbamoylmethyl-pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-3-methyl-butylcarbamoyl}-ethyl)-phenyl] ester

Guidance literature:

Multistep reaction;

DOI:10.1021/jm050513m

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

3-pyrrolidine ethanoic acid