N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

Base Information

Chemical Name:N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester
CAS No.:74193-71-8
Molecular Formula:C₂₉H₄₄N₂O₉
Molecular Weight:564.676
Hs Code.:

Synonyms:N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

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Chemical Property of N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

Chemical Property:

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Technology Process of N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

There total 1 articles about N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60686-50-2,60686-52-4
N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-L-γ-carboxyglutamic acid

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 74193-71-8
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, 2.) 4 deg C, 2 d;
DOI:10.1021/ja00530a017

Reference yield:

: 74193-71-8
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

: 74201-28-8
N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂, 2.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 10percent palladium/carbon / 1.) acetonitrile, room temperature, 3 h, 2.) 4 deg C

2: H₂ / 10percent palladium/carbon / acetonitrile / Ambient temperature

3: 77 percent / dimethylformamide / 48 h / 4 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00530a017

Reference yield:

: 74193-71-8
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

: 74193-74-1
L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂, 2.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 10percent palladium/carbon / 1.) acetonitrile, room temperature, 3 h, 2.) 4 deg C

2: H₂ / 10percent palladium/carbon / acetonitrile / Ambient temperature

3: 77 percent / dimethylformamide / 48 h / 4 °C

4: H₂O / 2.5 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00530a017