L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

Base Information

Chemical Name:L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt
CAS No.:74193-74-1
Molecular Formula:2C₂HF₃O₂*C₃₄H₄₉N₅O₁₄
Molecular Weight:979.836
Hs Code.:

Synonyms:L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

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Chemical Property of L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

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Technology Process of L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

There total 9 articles about L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 74193-74-1
L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine, 2.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) DMF, 2.) 4 deg C, 2 d

2: 1.) H₂, 2.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 10percent palladium/carbon / 1.) acetonitrile, room temperature, 3 h, 2.) 4 deg C

3: H₂ / 10percent palladium/carbon / acetonitrile / Ambient temperature

4: 77 percent / dimethylformamide / 48 h / 4 °C

5: H₂O / 2.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00530a017

Reference yield:

: 74193-71-8
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

: 74193-74-1
L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) H₂, 2.) 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) 10percent palladium/carbon / 1.) acetonitrile, room temperature, 3 h, 2.) 4 deg C

2: H₂ / 10percent palladium/carbon / acetonitrile / Ambient temperature

3: 77 percent / dimethylformamide / 48 h / 4 °C

4: H₂O / 2.5 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00530a017

Reference yield:

: 74193-72-9
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-γ,γ-di-tert-butyl-L-γ-carboxyglutamyl-L-leucine methyl ester

: 74193-74-1
L-phenylalanyl-L-leucyl-L-γ-carboxyglutamyl-L-γ-carboxyglutamyl-L-leucine methyl ester trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent palladium/carbon / acetonitrile / Ambient temperature

2: 77 percent / dimethylformamide / 48 h / 4 °C

3: H₂O / 2.5 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00530a017