[1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

Base Information

Chemical Name:[1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-
CAS No.:351415-08-2
Molecular Formula:C₂₄H₂₁F₃N₂O
Molecular Weight:410.439
Hs Code.:

Synonyms:[1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

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Chemical Property of [1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

Chemical Property:

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Technology Process of [1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

There total 6 articles about [1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256397-12-3
(S)-6-methyl-4'-trifluoromethylbiphenyl-2-carboxylic acid-(2-methoxycarbonylamino-indan-5-yl)-amide

: 351415-08-2
[1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; at 20 ℃;
DOI:10.1021/jm010294e

Reference yield:

: 256397-64-5
[6-METHYL-4'-(TRIFLUOROMETHYL)-[1, 1'-BIPHENYL]-2-CARBONYL]

: 351415-08-2
[1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0.25 h

2: Me₃SiI / acetonitrile / 20 °C

With pyridine; trimethylsilyl iodide; In dichloromethane; acetonitrile;
DOI:10.1021/jm010294e

Reference yield:

: 256397-61-2
6-methyl-4'-trifluoromethyl-1,1'-biphenyl-2-carboxylic acid

: 351415-08-2
[1,1'-biphenyl]-2-carboxamide, N-[(2S)-2-amino-2,3-dihydro-1H-inden-5-yl]-6-methyl-4'-(trifluoromethyl)-

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

2: pyridine / CH₂Cl₂ / 0.25 h

3: Me₃SiI / acetonitrile / 20 °C

With pyridine; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/jm010294e