Methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate

Base Information

Chemical Name:Methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate
CAS No.:256397-60-1
Molecular Formula:C16H13F3O2
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID901168808
Mol file:256397-60-1.mol

Synonyms:methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate;SCHEMBL4203346;DTXSID901168808;256397-60-1;methyl 6-methyl4'-trifluoromethyl-biphenyl-2-carboxylate;methyl 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylate;Methyl 6-methyl-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxylate;methyl 6-methyl-4'-trifluoromethyl- 1,1'-biphenyl-2-carboxylate;methyl 6-methyl-4'-trifluoromethyl-1,1'-biphenyl-2-carboxylate

Suppliers and Price of Methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:294.08676414
Heavy Atom Count:21
Complexity:359

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C(=O)OC)C2=CC=C(C=C2)C(F)(F)F

Technology Process of Methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate

There total 1 articles about Methyl 6-methyl-4'-trifluoromethylbiphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256397-60-1
6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid methyl ester

: (R)-6-Methyl-4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2-pyridylmethylamino)-indan-5-yl]-amide

Guidance literature:

Reference yield:

: 256397-60-1
6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid methyl ester

: 4-{(R)-5-[(6-Methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-piperazine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 9.59 g / 1 N aq. NaOH / ethanol / 5 h / Heating

2: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

3: 91 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

4: 89 percent / Me₃SiI / acetonitrile / 20 °C

5: 14 percent / iPr₂NEt / 3 h / Heating

With pyridine; sodium hydroxide; oxalyl dichloride; trimethylsilyl iodide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm010294e

Reference yield:

: 256397-60-1
6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid methyl ester

: 4-{(S)-5-[(6-Methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-yl}-piperazine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 9.59 g / 1 N aq. NaOH / ethanol / 5 h / Heating

2: oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

3: pyridine / CH₂Cl₂ / 0.25 h

4: Me₃SiI / acetonitrile / 20 °C

5: iPr₂NEt / 3 h / Heating

With pyridine; sodium hydroxide; oxalyl dichloride; trimethylsilyl iodide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm010294e