N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide

Base Information

• Chemical Name: N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide
• CAS No.: 1419600-04-6
• Molecular Formula: C₂₃H₂₇ClFN₅O₃S
• Molecular Weight: 508.016
• Mol file: 1419600-04-6.mol

Synonyms:N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide

Chemical Property of N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide

There total 4 articles about N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine (1254713-63-7) + 2-(5-fluoro-6-methanesulfonylamino-pyridin-3-yl)-propionic acid (1419603-79-4) → N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide (1419600-04-6)

Guidance literature:

2-(5-fluoro-6-methanesulfonylamino-pyridin-3-yl)-propionic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine; In N,N-dimethyl-formamide; at 23 ℃; for 4h;

Reference yield:

2-(5-fluoro-6-nitro-pyridin-3-yl)-propionic acid ethyl ester (1419603-73-8) → N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide (1419600-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium on carbon; hydrogen / ethanol / 2 h / 23 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 - 23 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 0 - 23 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

4.2: 4 h / 23 °C

With lithium hydroxide monohydrate; palladium on carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

2-(6-amino-5-fluoro-pyridin-3-yl)-propionic acid ethyl ester (1419603-75-0) → N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(5-fluoro-6-(methylsulfonamido)pyridin-3-yl)propanamide (1419600-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 0 - 23 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 0 - 23 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / Inert atmosphere

3.2: 4 h / 23 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2-(5-fluoro-6-nitro-pyridin-3-yl)-propionic acid ethyl ester

2-(6-amino-5-fluoro-pyridin-3-yl)-propionic acid ethyl ester

2-(5-fluoro-6-methanesulfonylamino-pyridin-3-yl)-propionic acid ethyl ester

(3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methanamine