5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Base Information

Chemical Name:5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol
CAS No.:1437779-36-6
Molecular Formula:C₂₁H₁₅BF₉NO₃
Molecular Weight:511.152
Hs Code.:

Synonyms:5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Suppliers and Price of 5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

There total 8 articles about 5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1437779-68-4
N,1-dihydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborole-5-carbimidoyl chloride

: 329-42-0
1,3-bis(trifluoromethyl)-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: 1437779-36-6
5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 73852-19-4
3,5-bis-trifluromethylphenylboronic acid

: 1437779-36-6
5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) oxide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 4 h / 80 °C / Sealed tube; Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 90971-88-3
methyl 2-bromo-5-methylbenzoate

: 1437779-36-6
5-(4-(3,5-bis(trifluoromethyl)phenyl)-4-(trifluoromethyl)-4,5-dihydro-isoxazol-5-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.2: 6 h / 20 °C

2.3: 3 h / 0 °C

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 12 h / Reflux

4.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 16 h / 20 °C

5.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 45 °C

6.1: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; ammonium chloride; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide;