(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide

Base Information

• Chemical Name: (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide
• CAS No.: 1472657-15-0
• Molecular Formula: C₂₀H₂₉ClN₂O₃S
• Molecular Weight: 412.981
• Mol file: 1472657-15-0.mol

Synonyms:(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide

Chemical Property of (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide

There total 3 articles about (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2-methylbenzenesulfonyl chloride (80563-86-6) → (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide (1472657-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water; methanol / 5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1002/cmdc.201300022

Reference yield:

cycloheptanamine (5452-35-7) + C13H16ClNO4S (1472657-63-8) → (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide (1472657-15-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/cmdc.201300022

Reference yield:

(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate (1472657-62-7) → (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide (1472657-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1002/cmdc.201300022

upstream raw materials:

cycloheptanamine

C₁₃H₁₆ClNO₄S

3-chloro-2-methylbenzenesulfonyl chloride

(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate