(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate

Base Information

• Chemical Name: (R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate
• CAS No.: 1472657-62-7
• Molecular Formula: C₁₄H₁₈ClNO₄S
• Molecular Weight: 331.82
• Mol file: 1472657-62-7.mol

Synonyms:(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate

Chemical Property of (R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate

There total 1 articles about (R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-chloro-2-methylbenzenesulfonyl chloride (80563-86-6) + (R)-piperidine-2-carboxylic acid methyl ester hydrochloride (18650-38-9) → (R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate (1472657-62-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/cmdc.201300022

Reference yield: 95.0%

(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate (1472657-62-7) → C13H16ClNO4S (1472657-63-8)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 5h;

DOI:10.1002/cmdc.201300022

Reference yield:

(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate (1472657-62-7) → (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide (1472657-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1002/cmdc.201300022

upstream raw materials:

3-chloro-2-methylbenzenesulfonyl chloride

(R)-piperidine-2-carboxylic acid methyl ester hydrochloride

Downstream raw materials:

(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide

(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-(tetrahydro-2H-pyran-4-yl)piperidine-2-carboxamide

(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-(1-benzylpiperidin-4-yl)piperidine-2-carboxamide