5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Base Information

Chemical Name:5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide
CAS No.:1403259-01-7
Molecular Formula:C₂₅H₃₄BrN₃O₃
Molecular Weight:504.467
Hs Code.:

Synonyms:5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

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Chemical Property of 5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

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Technology Process of 5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

There total 10 articles about 5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.9%

: 1346575-98-1
3-(aminomethyl)-6-methyl-4-(1-methylethyl)-2(1H)-pyridinone

: 1403257-81-7
5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl benzoic acid

: 1403259-01-7
5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 5166-53-0
5-methyl-3-hexene-2-one

: 1403259-01-7
5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / dimethyl sulfoxide / 1.5 h / 0 - 20 °C

2: hydrogen; ammonia / Raney nickel / water; methanol / 4 h / 20 °C

3: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

With potassium tert-butylate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; triethylamine; Raney nickel; In methanol; water; dimethyl sulfoxide;

Reference yield:

: 146881-63-2
4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1403259-01-7
5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-isopropyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; ammonia / Raney nickel / water; methanol / 4 h / 20 °C

2: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; triethylamine; Raney nickel; In methanol; water; dimethyl sulfoxide;