methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

Base Information

Chemical Name:methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate
CAS No.:109786-83-6
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:

Synonyms:methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

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Chemical Property of methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

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Technology Process of methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

There total 2 articles about methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 99500-31-9
1-(1H-imidazol-1-yl)-3-<(4-methoxyphenyl)methoxy>-2-propanone

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 109786-83-6
methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

Guidance literature:: In tetrahydrofuran; at 18 ℃; for 72h;
DOI:10.1021/jm00393a022

Reference yield:

: 84727-35-5
1-[2-hydroxy-3-[(4-methoxyphenyl)methoxy]propyl]-1H-imidazole

: 109786-83-6
methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -60 °C

2: 53 percent / tetrahydrofuran / 72 h / 18 °C

With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00393a022

Reference yield:

: 109786-83-6
methyl 4-(1H-imidazol-1-yl)-3-<<(4-methoxyphenyl)methoxy>methyl>-2-butenoate

: 109786-89-2
9-(1H-imidazol-1-yl)-8-{[(4-methoxyphenyl)methoxy]methyl}nonanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 12 h

2: DMSO, oxalyl chloride / CH₂Cl₂ / 0.25 h / -60 °C

3: 1.) KO-t-Bu / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 16 h

4: 85 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; hydrogen; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00393a022