3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one

Base Information

• Chemical Name: 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one
• CAS No.: 213338-82-0
• Molecular Formula: C₂₃H₃₀O₃Si
• Molecular Weight: 382.575
• Mol file: 213338-82-0.mol

Synonyms:3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one

Chemical Property of 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one

There total 2 articles about 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid (247216-14-4) → 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one (213338-82-0)

Guidance literature:

With benzenesulfonyl chloride; In pyridine; at 0 - 5 ℃;

DOI:10.1021/jo9906072

Reference yield:

4-((tert-butyldiphenylsilyl)oxy)butanoic acid (118715-16-5) → 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one (213338-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 1.5 h / 20 °C

1.2: 81 percent / tetrahydrofuran / 16 h

2.1: 76 percent / benzenesulfonyl chloride / pyridine / 0 - 5 °C

With benzenesulfonyl chloride; lithium diisopropyl amide; In tetrahydrofuran; pyridine; 1.1: Metallation / 1.2: Condensation / 2.1: Cyclization;

DOI:10.1021/jo9906072

Reference yield: 62.0%

3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one (213338-82-0) → tert-Butyl-[2-(2,2-dimethyl-4-methylene-oxetan-3-yl)-ethoxy]-diphenyl-silane (213338-86-4)

Guidance literature:

In toluene; at 75 - 80 ℃;

DOI:10.1021/jo9906072

upstream raw materials:

2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid

4-((tert-butyldiphenylsilyl)oxy)butanoic acid

Downstream raw materials:

tert-Butyl-[2-(2,2-dimethyl-4-methylene-oxetan-3-yl)-ethoxy]-diphenyl-silane