2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid

Base Information

• Chemical Name: 2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid
• CAS No.: 247216-14-4
• Molecular Formula: C₂₃H₃₂O₄Si
• Molecular Weight: 400.59
• Mol file: 247216-14-4.mol

Synonyms:2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid

Chemical Property of 2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid

There total 1 articles about 2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-((tert-butyldiphenylsilyl)oxy)butanoic acid (118715-16-5) + acetone (67-64-1) → 2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid (247216-14-4)

Guidance literature:

4-((tert-butyldiphenylsilyl)oxy)butanoic acid; With lithium diisopropyl amide; In tetrahydrofuran; at 20 ℃; for 1.5h;

acetone; In tetrahydrofuran; for 16h;

DOI:10.1021/jo9906072

Reference yield: 76.0%

2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid (247216-14-4) → 3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one (213338-82-0)

Guidance literature:

With benzenesulfonyl chloride; In pyridine; at 0 - 5 ℃;

DOI:10.1021/jo9906072

Reference yield:

2-(2-tert-butyldiphenylsilyloxy)ethyl-3-hydroxy-3-methylbutanoic acid (247216-14-4) → tert-Butyl-[2-(2,2-dimethyl-4-methylene-oxetan-3-yl)-ethoxy]-diphenyl-silane (213338-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / benzenesulfonyl chloride / pyridine / 0 - 5 °C

2: 62 percent / toluene / 75 - 80 °C

With benzenesulfonyl chloride; In pyridine; toluene; 1: Cyclization / 2: Substitution;

DOI:10.1021/jo9906072

upstream raw materials:

4-((tert-butyldiphenylsilyl)oxy)butanoic acid

acetone

Downstream raw materials:

3-(2-tert-butyldiphenylsilyloxy)ethyl-4,4-dimethyloxetan-2-one

tert-Butyl-[2-(2,2-dimethyl-4-methylene-oxetan-3-yl)-ethoxy]-diphenyl-silane