1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

Base Information

Chemical Name:1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate
CAS No.:1328884-51-0
Molecular Formula:C₂HF₃O₂*C₂₃H₃₀F₆N₂O
Molecular Weight:578.518
Hs Code.:

Synonyms:1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

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Chemical Property of 1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

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Technology Process of 1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

There total 8 articles about 1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 1328884-93-0
2-(1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-2-oxopyrrolidin-3-yl)acetaldehyde

: 76-05-1
trifluoroacetic acid

: 1328884-51-0
1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

Guidance literature:: piperidine; 2-(1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-2-oxopyrrolidin-3-yl)acetaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; for 3h; 4 ? Molecular sieve;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 1328884-89-4
C₁₂H₁₈O₂

: 1328884-51-0
1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; ozone / dichloromethane / -78 - 20 °C

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C

3.1: lithium hydroxide; methanol / water; tetrahydrofuran / 4 h / 20 °C

4.1: hydrogen / Lindlar catalyst / methanol / 2 h

5.1: ozone / acetone / -78 °C / Inert atmosphere

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 4 ? Molecular sieve

6.2: Waters Sunfire C₁₈

With methanol; sodium tetrahydroborate; hydrogen; sodium tris(acetoxy)borohydride; ozone; triphenylphosphine; lithium hydroxide; Lindlar catalyst; In tetrahydrofuran; methanol; dichloromethane; water; acetone;

Reference yield:

: 1328884-90-7
C₁₁H₁₆O₃

: 1328884-51-0
1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(2-(piperidin-1-yl)ethyl)pyrrolidin-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 0 - 20 °C

2.1: lithium hydroxide; methanol / water; tetrahydrofuran / 4 h / 20 °C

3.1: hydrogen / Lindlar catalyst / methanol / 2 h

4.1: ozone / acetone / -78 °C / Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 4 ? Molecular sieve

5.2: Waters Sunfire C₁₈

With methanol; sodium tetrahydroborate; hydrogen; sodium tris(acetoxy)borohydride; ozone; lithium hydroxide; Lindlar catalyst; In tetrahydrofuran; methanol; dichloromethane; water; acetone;