(3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

Base Information

Chemical Name:(3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester
CAS No.:187226-95-5
Molecular Formula:C₁₀H₁₆N₄O₄
Molecular Weight:256.261
Hs Code.:

Synonyms:(3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

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Chemical Property of (3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

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Technology Process of (3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

There total 10 articles about (3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187226-93-3
(1R,5R,6R)-5-Methoxymethoxy-7-aza-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid methyl ester

: 187226-95-5
(3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 65 - 70 ℃; for 21h;
DOI:10.1021/ja963036t

Reference yield:

: 187226-89-7
(3R,4S,5R)-5-Azido-4-hydroxy-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

: 187226-95-5
(3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / triethylamine; CH₂Cl₂ / 0.75 h / 0 °C

2: 1.) PPh₃, 2.) Et₃N / 1.) THF, rt, 3 h, rt, 2.) H₂O, THF, rt, 12 h

3: 2.95 g / NaN₃, NH₄Cl / dimethylformamide / 21 h / 65 - 70 °C

With sodium azide; ammonium chloride; triethylamine; triphenylphosphine; In dichloromethane; triethylamine; N,N-dimethyl-formamide;
DOI:10.1021/ja963036t

Reference yield:

: 187226-91-1
(3R,4S,5R)-5-Azido-4-methanesulfonyloxy-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

: 187226-95-5
(3R,4R,5S)-4-Amino-5-azido-3-methoxymethoxy-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) PPh₃, 2.) Et₃N / 1.) THF, rt, 3 h, rt, 2.) H₂O, THF, rt, 12 h

2: 2.95 g / NaN₃, NH₄Cl / dimethylformamide / 21 h / 65 - 70 °C

With sodium azide; ammonium chloride; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1021/ja963036t