Oseltamivir Acid Methyl Ester

Base Information

Chemical Name:Oseltamivir Acid Methyl Ester
CAS No.:208720-71-2
Molecular Formula:C₁₅H₂₆N₂O₄
Molecular Weight:298.382
Hs Code.:
UNII:VA6M0DID7C
Wikidata:Q27291721
Mol file:208720-71-2.mol

Synonyms:Oseltamivir Acid Methyl Ester;208720-71-2;VA6M0DID7C;methyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;Methyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)cyclohex-1-ene-1-carboxylate;methyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate;1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, methyl ester, (3R,4R,5S)-;UNII-VA6M0DID7C;SCHEMBL972924;Oseltamivir phosphate impurity E [EP];HY-147331;CS-0164985;CS-0566020;AB01563033_01;OSELTAMIVIR PHOSPHATE IMPURITY D [WHO-IP];J-013693;OSELTAMIVIR PHOSPHATE IMPURITY E [EP IMPURITY];Q27291721;(3R,4R,5S)-Methyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate;(3R,4R,5S)-Methyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate (Oseltamivir Impurity pound(c);METHYL (3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(1-ETHYLPROPOXY)CYCLOHEX-1-ENE-1-CARBOXYLATE

Suppliers and Price of Oseltamivir Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Oseltamivir Acid Methyl Ester
10mg
$ 460.00

Usbiological
Oseltamivir Acid Methyl Ester
10mg
$ 566.00

TRC
OseltamivirAcidMethylEster
25mg
$ 525.00

Total 8 raw suppliers

Chemical Property of Oseltamivir Acid Methyl Ester

Chemical Property:

Boiling Point:462.1±45.0 °C(Predicted)
PKA:14.65±0.70(Predicted)
PSA：94.14000
Density:1.10±0.1 g/cm3(Predicted)
LogP:2.43590
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:298.18925731
Heavy Atom Count:21
Complexity:405

Purity/Quality:

NLT 98% ^*data from raw suppliers

Oseltamivir Acid Methyl Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OC
Isomeric SMILES:CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OC
Uses Oseltamivir EP Impurity E It is a COVID19-related research product.

Technology Process of Oseltamivir Acid Methyl Ester

There total 9 articles about Oseltamivir Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (3R,4R,5S)-4-Acetylamino-5-azido-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester

: 208720-71-2
methyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; at 50 ℃; for 10h;

Reference yield:

: C₁₀H₁₆N₄O₄*ClH

: 208720-71-2
methyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 3 h / 0 - 20 °C

1.2: 22 h / 0 - 20 °C

2.1: boron trifluoride diethyl etherate / 1.75 h / 70 - 75 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: triphenylphosphine / water; tetrahydrofuran / 10 h / 50 °C

With boron trifluoride diethyl etherate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water;

Reference yield:

: 187226-93-3
(1R,5R,6R)-5-Methoxymethoxy-7-aza-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid methyl ester

: 208720-71-2
methyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 21 h / 65 - 70 °C

2.1: hydrogenchloride / methanol; water / 3 h / 20 °C

3.1: triethylamine / methanol / 3 h / 0 - 20 °C

3.2: 22 h / 0 - 20 °C

4.1: boron trifluoride diethyl etherate / 1.75 h / 70 - 75 °C / Inert atmosphere

4.2: 18 h / 20 °C

5.1: triphenylphosphine / water; tetrahydrofuran / 10 h / 50 °C

With hydrogenchloride; sodium azide; boron trifluoride diethyl etherate; ammonium chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;