3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester
• CAS No.: 1026672-88-7
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 1026672-88-7.mol

Synonyms:3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester

Chemical Property of 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester

There total 2 articles about 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methyl-4-oxo-3,1-benzoxazine (525-76-8) + ethyl 2-cyanoacetate (105-56-6) → 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester (1026672-88-7)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; 1.) r.t., 1 h, 2.) r.t., 2 h;

DOI:10.1039/p19960002909

Reference yield:

o-acetylamino-benzoic acid (89-52-1) → 3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester (1026672-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Ac₂O / 1 h / 130 °C

2: 95 percent / t-BuOK / 2-methyl-propan-2-ol / 1.) r.t., 1 h, 2.) r.t., 2 h

With potassium tert-butylate; acetic anhydride; In tert-butyl alcohol;

DOI:10.1039/p19960002909

Reference yield: 91.0%

3-(2-Acetylamino-phenyl)-2-cyano-3-oxo-propionic acid ethyl ester (1026672-88-7) → 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonitrile (15000-43-8)

Guidance literature:

With sodium ethanolate; In ethanol; 1.) reflux, 5 h, 2.) r.t., overnight;

DOI:10.1039/p19960002909

upstream raw materials:

2-methyl-4-oxo-3,1-benzoxazine

ethyl 2-cyanoacetate

o-acetylamino-benzoic acid

Downstream raw materials:

4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonitrile