methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Base Information

Chemical Name:methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate
CAS No.:1276687-36-5
Molecular Formula:C₂₂H₁₇F₃N₂O₄S
Molecular Weight:462.449
Hs Code.:

Synonyms:methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

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Chemical Property of methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

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Technology Process of methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

There total 6 articles about methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1276687-32-1
methyl (+/-)-5-(6-(4-methoxybenzyloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

: 1276687-36-5
methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm1011726

Reference yield:

: 5118-06-9
methyl 3-hydroxy-2-thiophenecarboxylate

: 1276687-36-5
methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid / 3 h / -10 - 0 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

3: iron; acetic acid / 2 h / 65 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

5: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

6: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; sulfuric acid; hydrogen; nitric acid; pyridinium p-toluenesulfonate; iron; caesium carbonate; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ethyl acetate; 2: Mitsunobu reaction / 4: Buchwald-Hartwig reaction;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-28-5
methyl (+/-)-5-(5-(4-methoxybenzyloxy)-2-nitrophenylamino)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

: 1276687-36-5
methyl (+/-)-5-(6-hydroxy-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With hydrogen; pyridinium p-toluenesulfonate; trifluoroacetic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jm1011726