4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

Base Information

Chemical Name:4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester
CAS No.:909569-45-5
Molecular Formula:C₁₆H₂₂O₅
Molecular Weight:294.348
Hs Code.:

Synonyms:4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

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Chemical Property of 4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

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Technology Process of 4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

There total 1 articles about 4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 909569-44-4
2-(2-(benzyloxy)ethyl)-3-oxobutyric acid methyl ester

: 107-21-1
ethylene glycol

: 909569-45-5
4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

Guidance literature:: With toluene-4-sulfonic acid; In water; benzene; at 110 ℃; for 20h;
DOI:10.1039/b803818j

Reference yield: 82.0%

: 909569-45-5
4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

: 909569-52-4
4-benzyloxy-2-(2-methyl-[1,3]-dioxolan-2-yl)butyric acid acid

Guidance literature:: With sodium hydroxide; water; In ethanol; at 70 ℃; for 3h;
DOI:10.1039/b803818j

Reference yield:

: 909569-45-5
4-benzyloxy-2-(2-methyl-1,3-dioxolan-2-yl)butyric acid acid methyl ester

: C₁₅H₂₁NO₅

Guidance literature:: Multi-step reaction with 12 steps

1: aq. NaOH / ethanol / 3 h / 70 °C

2: HOBt; EDC*HCl; NMM / CH₂Cl₂ / 0 - 20 °C

3: 71 percent / AcOH / H₂O / 96 h / 65 °C

4: 91 percent / 2,6-lutidine / CH₂Cl₂ / -78 - 0 °C

5: 82 percent / NaH / dimethylformamide / 14 h / 0 - 20 °C

6: 78 percent / Super-hydride / tetrahydrofuran; CH₂Cl₂ / 3 h / -78 °C

7: 87 percent / tetrahydrofuran / -78 °C

8: BCl₃*DMS / CH₂Cl₂ / 24 h / 0 - 20 °C

9: HF; H₂O / acetonitrile / 22 h / 20 °C

10: CAN / acetonitrile; H₂O / 1 h / 0 °C

11: [MeTeAlMe₂]2 / toluene / 24 h / 20 °C

12: BOP-Cl; pyridine / CH₂Cl₂ / 3 h / 20 °C

With 4-methyl-morpholine; pyridine; 2,6-dimethylpyridine; sodium hydroxide; ammonium cerium(IV) nitrate; boron trichloride - methyl sulfide complex; hydrogen fluoride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; lithium triethylborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/b607109k