N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

Base Information

Chemical Name:N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester
CAS No.:220019-09-0
Molecular Formula:C₁₈H₂₈N₄O₃
Molecular Weight:348.445
Hs Code.:

<i>N</i>'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-<i>N</i>'-methyl-hydrazinecarboxylic acid benzyl ester

Synonyms:N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

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Chemical Property of N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

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Technology Process of N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

There total 8 articles about N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 67-64-1
acetone

: 220019-08-9
N'-(2-aminomethyl-pyrrolidine-1-carbonyl)-N'-methyl-hydrazinecarboxylic acid benzyl ester

: 220019-09-0
N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

Guidance literature:: With sodium cyanoborohydride; In methanol; for 21h;
DOI:10.1021/jo980969u

Reference yield:

: 57699-92-0
2-benzyl 1-tert-butyl 1-methylhydrazine-1,2-dicarboxylate

: 220019-09-0
N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: AcCl / methanol / 0.33 h

2: aq. NaHCO₃ / CH₂Cl₂; toluene / 0.33 h / 0 °C

3: aq. NaHCO₃ / CH₂Cl₂ / 24 h

4: Et₃N / tetrahydrofuran / 0.33 h

5: NaN₃ / dimethylformamide / 16 h / 64 °C

6: 87 percent / Ph₃P, H₂O / tetrahydrofuran / 6 h / Heating

7: 98 percent / NaCNBH₃ / methanol / 21 h

With sodium azide; water; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; acetyl chloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo980969u

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 220019-09-0
N'-[2-(isopropylamino-methyl)-pyrrolidine-1-carbonyl]-N'-methyl-hydrazinecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: aq. NaOH / CH₂Cl₂ / 1 h

2: AcCl / methanol / 0.33 h

3: aq. NaHCO₃ / CH₂Cl₂; toluene / 0.33 h / 0 °C

4: aq. NaHCO₃ / CH₂Cl₂ / 24 h

5: Et₃N / tetrahydrofuran / 0.33 h

6: NaN₃ / dimethylformamide / 16 h / 64 °C

7: 87 percent / Ph₃P, H₂O / tetrahydrofuran / 6 h / Heating

8: 98 percent / NaCNBH₃ / methanol / 21 h

With sodium hydroxide; sodium azide; water; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; acetyl chloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo980969u