2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

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Chemical Name:2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide
CAS No.:921598-22-3
Molecular Formula:C₄₁H₄₅N₃O₆S
Molecular Weight:707.891
Hs Code.:

2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Synonyms:2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

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Chemical Property of 2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

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Technology Process of 2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

There total 16 articles about 2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3-{2-[((2R)-2-{4-benzyloxy-3-[(methylsulfonyl)amino]phenyl}-2-hydroxyethyl)amino]-2-methylpropyl}phenyl)-N-[(4'-hydroxybiphenyl-3-yl)methyl]-acetamide dibenzoyl-(L)-tartrate salt

: 921598-22-3
2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Guidance literature:: With ammonia; In tetrahydrofuran; water; for 0.25h; Product distribution / selectivity;

Reference yield:

: 865589-97-5
3'-(aminomethyl)biphenyl-4-ol hydrochloride

: 921598-22-3
2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 12 h / 50 °C

3.1: acetic acid / 15.5 h / 70 °C / Reflux

4.1: butironitrile / 20 h / Reflux

5.1: sodium hydroxide / ethanol; water / 20 °C

With benzotriazol-1-ol; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; butironitrile; water; 2.1: Ritter reaction;
DOI:10.1021/op2002408

Reference yield:

: 2-chloro-N-{2-[3-(2-{[(4'-hydroxybiphenyl-3-yl)methyl]amino}-2-oxoethyl)phenyl]-1,1-dimethylethyl}acetamide

: 921598-22-3
2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 15.5 h / 70 °C / Reflux

2: butironitrile / 20 h / Reflux

3: sodium hydroxide / ethanol; water / 20 °C

With acetic acid; sodium hydroxide; In ethanol; butironitrile; water;
DOI:10.1021/op2002408