(S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol

Base Information

• Chemical Name: (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol
• CAS No.: 361520-05-0
• Molecular Formula: C₁₂H₁₇NO₄
• Molecular Weight: 239.271
• Mol file: 361520-05-0.mol

Synonyms:(S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol

Chemical Property of (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol

There total 3 articles about (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-2-methoxycarbonylamino-3-(4-methoxyphenyl)-propionic acid methyl ester (113089-15-9) → (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol (361520-05-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol015526i DOI:10.1021/ja016030z

Reference yield:

(S)-3-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino] propionic acid (338386-45-1) → (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol (361520-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.202004444

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol (361520-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; tetrahydrofuran / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1002/chem.202004444

upstream raw materials:

(S)-2-methoxycarbonylamino-3-(4-methoxyphenyl)-propionic acid methyl ester

(S)-3-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino] propionic acid

L-tyrosine

Downstream raw materials:

[(S)-1-Formyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid methyl ester