2-PHENYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-PHENYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID
• CAS No.: 66630-70-4
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.246
• Hs Code.: 2933290090

Synonyms:1H-Benzimidazole-5-carboxylicacid, 2-phenyl- (9CI);5(Or 6)-Benzimidazolecarboxylic acid, 2-phenyl- (7CI);

Chemical Property of 2-PHENYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 5.85E-12mmHg at 25°C
• Refractive Index: 1.717
• Boiling Point: 527.6 °C at 760 mmHg
• Flash Point: 272.9 °C
• PSA: 65.98000
• Density: 1.377 g/cm³
• LogP: 2.92810

Purity/Quality:

97% ^*data from raw suppliers

2-Phenyl-3H-benzimidazole-5-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID

There total 16 articles about 2-PHENYL-3H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzaldehyde (100-52-7) + 3,4-diaminobenzoic acid (619-05-6) → 2-phenyl-1H-1,3-benzimidazole-5-carboxylic acid (66630-70-4)

Guidance literature:

With ammonium acetate; In ethanol; at 75 ℃; for 5.5h;

DOI:10.1080/00397910701863657

Reference yield: 95.0%

ethyl 2-phenyl-1H-benzo[d]imidazole-6-carboxylate → 2-phenyl-1H-benzo[d]imidazole-6-carboxylic acid (66630-70-4)

Guidance literature:

With methanol; potassium hydroxide; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejic.202100294

Reference yield: 85.0%

ethyl 2‐phenyl‐1H‐benzimidazole‐5‐carboxylate → 2-phenyl-1H-1,3-benzimidazole-5-carboxylic acid (66630-70-4)

Guidance literature:

With water; sodium hydroxide; at 60 ℃; for 6h;

upstream raw materials:

5-methyl-2-phenyl-1H-1,3-benzimidazole

benzaldehyde

3,4-diaminobenzoic acid

sodium hydroxy(phenyl)methanesulfonate

Downstream raw materials:

C₂₈H₂₅N₃O₄

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