4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Base Information

Chemical Name:4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide
CAS No.:1443763-63-0
Molecular Formula:C₃₁H₂₆F₄N₆O₃
Molecular Weight:606.579
Hs Code.:

Synonyms:4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Suppliers and Price of 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

There total 11 articles about 4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1443763-63-0
4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1 h / -78 - 0 °C

2.1: potassium hydroxide; water / ethanol / 4 h / 0 °C

3.1: ethyl acetate / Reflux

4.1: sodium hydrogencarbonate; HATU / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With water; sodium hydrogencarbonate; HATU; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1443763-93-6
4-{[6-(4-aminophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

: 150360-26-2
(2R)-2-(4-fluorophenyl)propanoic acid

: 1443763-63-0
4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Guidance literature:: With sodium hydrogencarbonate; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1010120-60-1
ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate

: 1443763-63-0
4-{[6-(4-{[(2R)-2-(4-fluorophenyl)propanoyl]-amino}phenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-3-methoxy-N-(2,2,2-trifluoroethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 2 h / 60 °C

2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / propan-1-ol / 4 h / Reflux

3: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene; 1-methyl-pyrrolidin-2-one / 16 h / Inert atmosphere; Reflux

4: trifluoroacetic acid / dichloromethane / 9 h / 20 °C

5: sodium hydrogencarbonate; HATU / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; XPhos; In 1-methyl-pyrrolidin-2-one; methanol; propan-1-ol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;