3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

Base Information

Chemical Name:3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole
CAS No.:1260022-59-0
Molecular Formula:C₁₈H₁₅BrClFN₂O₃
Molecular Weight:441.684
Hs Code.:

Synonyms:3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

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Chemical Property of 3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

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Technology Process of 3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

There total 1 articles about 3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260022-41-0
3-bromo-5-fluoro-N-hydroxy-2-(methyloxy)benzenecarboximidamide

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1260022-59-0
3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

Guidance literature:: 3-chloro-4-isopropoxy-benzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; In tetrahydrofuran; at 20 ℃; for 1h;

3-bromo-5-fluoro-N-hydroxy-2-(methyloxy)benzenecarboximidamide; In tetrahydrofuran; at 20 ℃; for 1h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 120 ℃; for 2h; Sealed; Microwave irradiation;

Reference yield:

: 1260022-59-0
3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

: 193065-68-8
(3-ethoxy-3-oxopropyl)zinc(II) bromide

: 1260022-62-5
ethyl 3-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-fluoro-2-(methyloxy)phenyl]propanoate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1260022-59-0
3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-5-{3-chloro-4-[(1-methylethyl)oxy] phenyl}-1,2,4-oxadiazole

: 151073-69-7
(4-ethoxy-4-oxobutyl)zinc(II) bromide

: 1260022-65-8
ethyl 4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-fluoro-2-(methyloxy)phenyl]butanoate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;