2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide
CAS No.:883104-83-4
Molecular Formula:C₁₈H₂₂F₃NO₆
Molecular Weight:405.371
Hs Code.:

2,2,2-trifluoro-<i>N</i>-methoxy-<i>N</i>-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-<i>d</i>][1,3]dioxin-8-yl)-acetamide

Synonyms:2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

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Chemical Property of 2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

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Technology Process of 2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

There total 1 articles about 2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 883104-82-3
N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-O-methyl-hydroxylamine

: 407-25-0
trifluoroacetic anhydride

: 883104-83-4
2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1055/s-2006-926231

Reference yield: 94.0%

: 883104-83-4
2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

: 98758-31-7
methyl 4,6-O-benzylidene-2,3-dideoxy-3-C-methyl-3-(trifluoroacetamido)-α-D-ribo-hexopyranoside

Guidance literature:: With samarium diiodide; In tetrahydrofuran; methanol; at 20 ℃; for 0.166667h;
DOI:10.1055/s-2006-926231

Reference yield:

: 883104-83-4
2,2,2-trifluoro-N-methoxy-N-(6-methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-acetamide

: 95087-00-6,95087-01-7
4-O-benzoyl-2,3,6-trideoxy-3-C-methyl-3-trifluoroacetamido-αβ-L-lyxo-hexopyranose

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / SmI₂ / methanol; tetrahydrofuran / 0.17 h / 20 °C

2: 73 percent / NBS; pyridine / CCl₄ / 2.5 h / Heating

3: 76 percent / DBU / dimethylformamide / 4 h / 90 °C

4: 67 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

5: aq. AcOH / 12 h / 100 °C

With pyridine; N-Bromosuccinimide; samarium diiodide; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926231