(R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate

Base Information

• Chemical Name: (R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate
• CAS No.: 1206515-16-3
• Molecular Formula: C₁₆H₁₃F₆N₃O₅
• Molecular Weight: 441.287

Synonyms:(R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate

Chemical Property of (R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate

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Technology Process of (R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate

There total 1 articles about (R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(3-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine (205485-24-1) + (R)-N-trifluoroacetylaspartic acid-4-chloride-1-methyl ester (161553-08-8) → (R)-methyl 4-(4-methoxy-2-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate (1206515-20-9) + (R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate (1206515-16-3)

Guidance literature:

With trifluorormethanesulfonic acid; at 0 ℃; for 2h;

DOI:10.1271/bbb.90027

Reference yield: 88.0%

(R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate (1206515-16-3) → (R)-2-amino-4-(2-methoxy-4(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxobutanoic acid (1206515-19-6)

Guidance literature:

With hydrogenchloride; water; acetic acid; at 50 ℃; for 12h;

DOI:10.1271/bbb.90027

Reference yield: 80.0%

(R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxo-2-(2,2,2-trifluoroacetamido)butanoate (1206515-16-3) → (R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-2-(2,2,2-trifluoroacetamido)butanoate (1206515-17-4)

Guidance literature:

With triethylsilane; trifluoroacetic acid; for 2h;

DOI:10.1271/bbb.90027

upstream raw materials:

3-(3-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine

(R)-N-trifluoroacetylaspartic acid-4-chloride-1-methyl ester

Downstream raw materials:

(R)-methyl 4-(2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-2-(2,2,2-trifluoroacetamido)butanoate

(R)-2-amino-4-(2-methoxy-4(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)-4-oxobutanoic acid

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