4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

Base Information

Chemical Name:4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate
CAS No.:1355067-22-9
Molecular Formula:C₂₂H₁₆Cl₂FNO₃
Molecular Weight:432.278
Hs Code.:

Synonyms:4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

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Chemical Property of 4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

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Technology Process of 4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

There total 6 articles about 4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1355067-18-3
5-chloro-6-cyclopropylpyridin-3-ol

: 1354960-64-7
4-methylphenyl 5-chloro-2,4-difluorobenzoate

: 1355067-22-9
4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 3h;

Reference yield:

: 96424-68-9
2-bromo-3-chloropyridine

: 1355067-22-9
4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 6 h / 100 °C / Inert atmosphere

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C / Inert atmosphere

3: Oxone / water; acetone / 1 h / 0 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

With Oxone; potassium phosphate; potassium carbonate; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; palladium diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine; tricyclohexylphosphine; In n-heptane; water; dimethyl sulfoxide; acetone; toluene;

Reference yield:

: 1355066-87-3
3-chloro-2-cyclopropylpyridine

: 1355067-22-9
4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C / Inert atmosphere

2: Oxone / water; acetone / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

With Oxone; potassium carbonate; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In n-heptane; water; dimethyl sulfoxide; acetone;