3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

Base Information

Chemical Name:3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine
CAS No.:617700-09-1
Molecular Formula:C₁₂H₂Cl₂F₆I₂N₄
Molecular Weight:640.88
Hs Code.:

Synonyms:3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

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Chemical Property of 3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

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Technology Process of 3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

There total 8 articles about 3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 617700-08-0
3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diaziridine

: 617700-09-1
3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

Guidance literature:: With iodine; triethylamine; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jo034520z

Reference yield:

: 617699-98-6
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoroacetylpyrazole

: 617700-09-1
3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 55 percent / I₂ / tetrahydrofuran / 2 h / 20 °C

3.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

4.1: 96 percent / hydroxylamine hydrochloride / pyridine; ethanol / 14 h / 50 °C

5.1: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

6.1: 92 percent / NH₃ gas / diethyl ether / -78 - 20 °C

7.1: 94 percent / Et₃N; I₂ / methanol / 2 h / 20 °C

With dmap; sodium tetrahydroborate; hydroxylamine hydrochloride; ammonia; iodine; Dess-Martin periodane; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo034520z

Reference yield:

: 617699-97-5
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole

: 617700-09-1
3-{4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]}-3-(trifluoromethyl)diazirine

Guidance literature:: Multi-step reaction with 8 steps

1.1: iPrMgCl / tetrahydrofuran / 1 h / 0 °C

1.2: 79 percent / tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 55 percent / I₂ / tetrahydrofuran / 2 h / 20 °C

4.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

5.1: 96 percent / hydroxylamine hydrochloride / pyridine; ethanol / 14 h / 50 °C

6.1: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 20 °C

7.1: 92 percent / NH₃ gas / diethyl ether / -78 - 20 °C

8.1: 94 percent / Et₃N; I₂ / methanol / 2 h / 20 °C

With dmap; sodium tetrahydroborate; hydroxylamine hydrochloride; ammonia; iodine; isopropylmagnesium chloride; Dess-Martin periodane; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo034520z