1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

Base Information

Chemical Name:1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole
CAS No.:617700-02-4
Molecular Formula:C₁₂H₆Cl₂F₆N₂O
Molecular Weight:379.089
Hs Code.:

Synonyms:1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

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Technology Process of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

There total 2 articles about 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 617699-98-6
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoroacetylpyrazole

: 617700-02-4
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 3h;
DOI:10.1021/jo034520z

Reference yield:

: 617699-97-5
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole

: 617700-02-4
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPrMgCl / tetrahydrofuran / 1 h / 0 °C

1.2: 79 percent / tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 97 percent / NaBH₄ / ethanol / 3 h / 20 °C

With sodium tetrahydroborate; isopropylmagnesium chloride; In tetrahydrofuran; ethanol;
DOI:10.1021/jo034520z

Reference yield: 55.0%

: 617700-02-4
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole

: 1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]iodopyrazole

: 617700-03-5
1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]-5-iodopyrazole

Guidance literature:: 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-[1-hydroxy-(2,2,2-trifluoroethyl)]pyrazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

With iodine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo034520z