2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

Base Information

Chemical Name:2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid
CAS No.:1566584-46-0
Molecular Formula:C₃₀H₃₇N₅O₄
Molecular Weight:531.655
Hs Code.:

Synonyms:2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

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Chemical Property of 2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

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Technology Process of 2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

There total 11 articles about 2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1566584-45-9
tert-butyl 4-(5-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

: 1566584-46-0
2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 40 ℃; for 18h;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1566584-46-0
2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

4: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 44 h / 20 °C

5: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 4487-59-6
2-bromo-5-nitropyridine

: 1566584-46-0
2-(2-(2-(2-((6-(1-(tert-butoxycarbonyl)piperidin-4-yl)pyridin-3-yl)amino)-5-methylpyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

4: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 44 h / 20 °C

5: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;