(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

Base Information

Chemical Name:(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate
CAS No.:1157846-15-5
Molecular Formula:C₁₆H₁₉NO₄
Molecular Weight:289.331
Hs Code.:

Synonyms:(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

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Chemical Property of (1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

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Technology Process of (1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

There total 1 articles about (1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1157846-06-4
(2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-phenylpyrrolidine-2-carboxylic acid

: 1157846-15-5
(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2009.01.063

Reference yield: 49.0%

: 6'-amino-2H-[1,3^,-bipyridin]-2-one

: 1157846-15-5
(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 1157846-23-5
(2R,4S)-tert-butyl 4-hydroxy-2-((5-(2-oxopyridin-1(2H)-yl)pyridin-2-yl)carbamoyl)-4-phenylpyrrolidine-1-carboxylate

Guidance literature:: 6'-amino-2H-[1,3^,-bipyridin]-2-one; With trimethylaluminum; In toluene; at 0 - 20 ℃; Inert atmosphere;

(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate; In toluene; at 100 ℃; for 5h; Inert atmosphere;

With water; In toluene; at 0 ℃;
DOI:10.1016/j.bmc.2009.01.063

Reference yield:

: 107818-55-3
3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

: 1157846-15-5
(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 1330784-42-3
tert-butyl 2-{[5-bromo-2-(methoxycarbonyl)thiophen-3-yl]carbamoyl}-4-hydroxy-4-phenylpyrrolidine-1-carboxylate

Guidance literature:: 3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h;

(1R,4S)-tert-butyl 6-oxo-4-phenyl-5-oxa-2-azabicyclo[2.2.1]heptane-2-carboxylate; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; In tetrahydrofuran; water;