methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate

Base Information

• Chemical Name: methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate
• CAS No.: 1421838-42-7
• Molecular Formula: C₃₅H₄₀N₂O₆
• Molecular Weight: 584.712
• Mol file: 1421838-42-7.mol

Synonyms:methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate

Chemical Property of methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate

There total 9 articles about methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-2-methylpropionic acid methyl ester (23426-63-3) + C30H32N2O4 (1421837-32-2) → methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate (1421838-42-7)

Guidance literature:

With caesium carbonate; In acetonitrile; at 70 ℃; for 8h;

Reference yield:

2-(4-(2-(3,5-dimethylisoxazol-4-yl)-2-oxoethoxy)phenyl)-N-((2,4-dimethylphenyl)(phenyl)methyl)acetamide (1421838-41-6) → methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate (1421838-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

2: caesium carbonate / acetonitrile / 8 h / 70 °C

With sodium tetrahydroborate; caesium carbonate; In methanol; acetonitrile;

Reference yield:

3,5-dimethyl-4-isoxazolecarboxylic acid (2510-36-3) → methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate (1421838-42-7)

Guidance literature:

Multi-step reaction with 9 steps

1: thionyl chloride / 70 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

4: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C

5: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C

6: bromine; acetic acid / tetrachloromethane / 0.33 h / 48 °C

7: potassium carbonate / acetonitrile / 8 h / 70 °C / Inert atmosphere

8: sodium tetrahydroborate / methanol / 0.5 h / 20 °C

9: caesium carbonate / acetonitrile / 8 h / 70 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; bromine; potassium carbonate; caesium carbonate; Dess-Martin periodane; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; acetonitrile;

upstream raw materials:

2-(4-(2-(3,5-dimethylisoxazol-4-yl)-2-oxoethoxy)phenyl)-N-((2,4-dimethylphenyl)(phenyl)methyl)acetamide

2-bromo-2-methylpropionic acid methyl ester

C₃₀H₃₂N₂O₄

3,5-dimethyl-4-isoxazolecarboxylic acid

Downstream raw materials:

C₃₄H₃₈N₂O₆