H-GLY-LEU-OME HCL

Base Information

• Chemical Name: H-GLY-LEU-OME HCL
• CAS No.: 4249-25-6
• Molecular Formula: C₉H₁₈N₂O₃*ClH
• Molecular Weight: 238.714
• Mol file: 4249-25-6.mol

Synonyms:L-Leucine,N-glycyl-, methyl ester, monohydrochloride; L-Leucine, glycyl-, methyl ester,monohydrochloride (9CI); Leucine, N-glycyl-, methyl ester, monohydrochloride,L- (8CI); Glycylleucine methyl ester hydrochloride; N-Glycyl-L-leucine methylester hydrochloride

Chemical Property of H-GLY-LEU-OME HCL

Chemical Property:

• PSA: 81.42000
• LogP: 1.54220

Purity/Quality:

95%;98%;99% ^*data from raw suppliers

H-GLY-LEU-OME HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-GLY-LEU-OME HCL

There total 6 articles about H-GLY-LEU-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-4-methylpentanoate (7535-69-5) → N--L-leucine methyl ester hydrochloride (4249-25-6,5191-88-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.cclet.2021.09.102

Reference yield:

N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)glycyl]-L-leucine methyl ester (188783-05-3) → N--L-leucine methyl ester hydrochloride (4249-25-6,5191-88-8) + 5-phenyl-4-ethoxycarbonylpyrazole

Guidance literature:

With hydrazine hydrochloride; In methanol; for 5h; Heating;

DOI:10.1002/jhet.5570340128

Reference yield:

N-benzyloxycarbonylglycyl-L-leucine methyl ester (17331-93-0) → N--L-leucine methyl ester hydrochloride (4249-25-6,5191-88-8)

Guidance literature:

With hydrogenchloride; palladium; In methanol;

upstream raw materials:

N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)glycyl]-L-leucine methyl ester

N-benzyloxycarbonylglycyl-L-leucine methyl ester

(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-4-methylpentanoate

methyl (L)-leucinate hydrochloride

Downstream raw materials:

Z-Ser-Tyr-Gly-Leu-OMe

Refernces

• 1、 Metrano, Anthony J.,Abascal, Nadia C.,Mercado, Brandon Q.,Paulson, Eric K.,Hurtley, Anna E.,Miller, Scott J.. "Diversity of Secondary Structure in Catalytic Peptides with β-Turn-Biased Sequences". supporting information. p. 492 - 516. Retrieved 2017/02/23.
• 2、 Furukawa, Tadashi,Akutagawa, Takashi,Funatani, Hitomi,Uchida, Toshikazu,Hotta, Yoshihiro,Niwa, Masatake,Takaya, Yoshiaki. "Cyclic dipeptides exhibit potency for scavenging radicals". experimental part. p. 2002 - 2009. Retrieved 2012/05/04.