17331-93-0Relevant articles and documents
Development of hydrophilic polyacrylamide gel-based condensing reagents comprised of chlorotriazine
Yamada, Kohei,Hirozawa, Shota,Xia, Junqing,Kunishima, Munetaka
, p. 534 - 537 (2020/07/31)
Hydrophilic polyacrylamide gel-based triazine-type condensing reagents, PAG-Trz-Cl, have been developed. PAG-Trz-Cls were synthesized using a chlorotriazine with an acrylamide moiety, acrylamide, and N,N'-methylenebisacrylamide via both precipitation and
One-step C-terminal deprotection and activation of peptides with peptide amidase from stenotrophomonas maltophilia in neat organic solvent
Arif, Muhammad I.,Toplak, Ana,Szymanski, Wiktor,Feringa, Ben L.,Nuijens, Timo,Quaedflieg, Peter J. L. M.,Wu, Bian,Janssen, Dick B.
, p. 2197 - 2202 (2014/07/21)
Chemoenzymatic peptide synthesis is a rapidly developing technology for cost effective peptide production on a large scale. As an alternative to the traditional C→N strategy, which employs expensive N-protected building blocks in each step, we have investigated an N→C extension route that is based on activation of a peptide C-terminal amide protecting group to the corresponding methyl ester. We found that this conversion is efficiently catalysed by Stenotrophomonas maltophilia peptide amidase in neat organic media. The system excludes the possibility of internal peptide cleavage as the enzyme lacks intrinsic protease activity. The produced peptide methyl ester was used for peptide chain extension in a kinetically controlled reaction by a thermostable protease.
Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid
Whitteck, John T.,Ni, Weijuan,Griffin, Benjamin M.,Eliot, Andrew C.,Thomas, Paul M.,Kelleher, Neil L.,Metcalf, William W.,Van Der Donk, Wilfred A.
, p. 9089 - 9092 (2008/09/20)
(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of
